The world’s most famous painting was painted sometime between 1503 and 1509 by the italian painter draftsmans , sculptor , architect and engineer leonardo da vinci . The sitter’s mysterious smile and her proven identity have made the painting a source of ongoing investigation and fascination . Much speculation and debate regarding the identity of the potrait sitter led to suggestions . Leonardo mother caterina , leonardo’s self potrait . lisa del giocondo and the wife of florentine merchant . Foresenic experts in 2013 opened teh tomb of teh giocondo family in florence in order to find lisa del giocondo’s remains test her dna and recreate an image of her face .
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